Bioburden is the number of bacteria living on an un-sterilised surface.
GMP Draft Annex 1 describes it as "The total number of microorganisms associated with a specific item prior to sterilization."
See rotational cleaning for information on how to control bioburden.
What is Rotational Cleaning?
EU GMP Annex 1 states that more than one type of disinfecting agent with different modes of action s...Read more